I appreciate that you can rebind hotkeys for your implants and whatnot, but I think it might have been best if they had left out many of the new ones. Other hotkeys streamline gameplay in a similar manner, to the detriment of tense moments where you're cornered and have to improvise a way to get out of a sticky situation. Also notable is that there used to be a functional difference between dry reloads and tactical reloads, since you had to click once to unload a partially unspent magazine and again to load the desired ammunition type - a reload hotkey merges these functions and removes another element that you had to keep track of. Since reloading is instant save for the time it takes to mouse over from your target to the reload button, a reload hotkey renders magazine capacities as essentially pointless. SS1's combat is already rather straightforward with the mouselook mod, and much of the tension and challenge that was still there came from managing so many things manually in the interface in the midst of danger.
I think it's a bad idea to use many of the hotkeys they've made available to you, such as reload/healing patch/grenade/quick pickup hotkeys.